I agree with the female socket strips along both sides, but I'm not sure about using a 40-pin ZIF socket - you're not likely to be removing and refitting devices much (since you'll have an ICP connector on the board), and machine screw sockets like on the Gooligum board would be cheaper, and you should be able to squeeze some 0.3" span sockets inside the 0.6" 40-pin ones. Of course, you can make the decision between machine screw sockets and a single ZIF socket at the time when you assign the board to a project.
Also, I agree with Bob that you're not likely to need to remove the PIC once you've allocated the board to a project, and the PCB itself will be cheap. But that's not the full story because of the cost of the optional circuitry - for example, H-bridge ICs aren't cheap and you might not want to install them on every board you get, and it's not ideal to be installing them after the PIC has been fitted. But once you have an idea for a project to allocate a blank board for, you could install the required support components, then install an SMT PIC device, and commit the board to that project, so effectively, Bob is right, I think.
Yes, something like that. Download the data sheets for a variety of PICs and use them to determine the common pin allocations - for example, a lot of them have VDD and VSS on the northernmost pins - and to see what peripherals they have and how they can be routed to pins. Create a document - perhaps on Google Docs - listing the devices, their peripherals and their pin allocations. Then add support circuitry on the board.
I suggest adding support for a 32 kHz watch crystal for timekeeping, possibly along with a battery backup circuit; some motor driving circuitry (with a separate supply rail) - three or four single-ended drivers for stepper motors, and two or three H-bridges for brushed DC motors or stepper motors, and other circuitry to support the PIC peripherals that interest you.
The Gooligum board is probably a good source of information again. It looks like it uses 0.1" pin headers and jumper shunts to connect PIC pins to external circuitry.