Professional without free or cheap versions:
Altium, I'm unfortunately aware of they took over Protel. I used Protel up till earlier this year. Very respectable software
All the PCB's I do for my commercial manufacturing have been done with it.
Unfortunately it wont run on Win7 ( it did on my old XP puter)
when I enquired about an upgrade They wanted AU$7,500 .... yeah like that's going to happen
so unless I can find another prog that can read my xxx.DDB or xxx.PCB files, I'm going to have to set up an old PC just to be able to access my PCB layout files grrrrrrrrrrrr
Dave